Beneficial Effect of Rituximab in the Treatment of Esophageal Cancer–Associated Pauci-Immune Glomerulonephritis
نویسندگان
چکیده
Heleen Ameye, Sabine Fransis, Evelyne Lerut, Christoph Metalidis and Ben Sprangers Department of Nephrology, University Hospitals Leuven, Leuven, Belgium; Department of Pathology, Ziekenhuis OostLimburg Hospital, Genk, Belgium; Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium; Department of Nephrology, Ziekenhuis Oost-Limburg Hospital, Genk, Belgium; and Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium
منابع مشابه
The Prevalence and Management of Pauci-Immune Glomerulonephritis and Vasculitis in Western Countries.
BACKGROUND Pauci-immune glomerulonephritis is the most common cause of aggressive glomerulonephritis and occurs as a renal-limited disease or as a component of systemic necrotizing small-vessel vasculitis. It is characterized by paucity of staining for immunoglobulins, by immunofluorescence along with fibrinoid necrosis and crescent formation by light microscopy, while the vast majority of pati...
متن کاملTreatment of ANCA-associated systemic vasculitis.
The antineutrophil cytoplasmic antibodies (ANCA)-associated small vessel vasculitides include Wegener's granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis (MPA), and the renal limited form of MPA, also known as pauci-immune or idiopathic crescentic glomerulonephritis. ANCA are probably necessary but not sufficient for disease pathogenicity. Classical induction and maintenance ther...
متن کاملMonoclonal gammopathy-associated pauci-immune extracapillary-proliferative glomerulonephritis successfully treated with bortezomib
Extracapillary-proliferative glomerulonephritis is a rare complication of multiple myeloma. Partial remission of kidney involvement with cyclophosphamide therapy has previously been described. We report the case of a 60-year-old male patient diagnosed with rapidly progressive glomerulonephritis associated with IgG kappa monoclonal gammopathy. His kidney biopsy revealed pauci-immune extracapilla...
متن کاملAP-VAS 2012 case report: a case of ANCA-negative pauci-immune crescentic glomerulonephritis associated with IL-6-producing adenosquamous cell carcinoma of the lung.
A 76-year-old man with lung cancer and multiple metastases was admitted for purpura and rapidly progressive glomerulonephritis. Adenosquamous cell carcinoma of the lung had been diagnosed 6 months earlier. Two anti-cancer drug regimens had no effect. At admission, his survival with his malignancy was estimated to be several months. Renal biopsy revealed pauci-immune necrotizing crescentic glome...
متن کاملGlomerular Disease in Patients with Infectious Processes Developing Antineutrophil Cytoplasmic Antibodies
To identify differences in treatment and outcome of various types of glomerulonephritis developing in the course of infections triggering antineutrophil cytoplasmic antibody (ANCA) formation, we analyzed published reports of 50 patients. Immunosuppressives were added to antibiotics in 22 of 23 patients with pauci-immune glomerulonephritis. Improvement was noted in 85% of 20 patients with inform...
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